Effect of catecholamines and ovarian hormones on cyclic AMP accumulation in rat hypothalamus.
نویسندگان
چکیده
Effect of different monoamines and estradiol were studied on cyclic AMP (CAMP) accumulation in hypothalami from 21 day old female rats. Incubation for 5 min with 10D4r/r epinephrine, norepinephrine or dopamine resulted in an increase in c!AMP accumulation in the hypothals$%s. Incubation of hypothalamic tissue with estradiol (4 x 10 M to 2 x 10 -5M) also resulted in an increase in cyclic AMP levels. The increase caused by estradiol was observed only after 50 min of incubation period. The estradiol induced increase in cyclic AMP accumulation was abolished by both 01 and S blockers. These results suggest that the estradiol-induced increase in cyclic AMP may be mediated by a prior increase in catecholamines in the hypothalamic tissue.
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ورودعنوان ژورنال:
- Biochemical and biophysical research communications
دوره 54 1 شماره
صفحات -
تاریخ انتشار 1973